Effects of the Antifungal Peptide Ro 2-7758 on Morphology of Mucor Corymbifera.

Gale, Glen R. (Veterans Administration Hospital and Duke University Medical Center, Durham, N.C.). Effects of the antifungal peptide Ro 2-7758 on morphology of Mucor corymbifera. J. Bacteriol. 85:833-837. 1963.-Hyphae of Mucor corymbifera grown in the presence of the antifungal peptide, Ro 2-7758, were examined in an electron microscope. The predominant change, compared with control hyphae, was a marked thickening of the cell wall, with apparent maintenance of normal structure. Cell walls of control hyphae were from 0.03 to 0.11 mu in thickness; drug-treated walls varied from 0.22 to over 0.75 mu in thickness. The possible sites and mechanisms of action, as well as the significance of a thickened cell wall in antibiosis, are discussed.